2022 Karle Symposium Recap

The 2022 Karle Symposium was held in the chemistry building last week. The Karle symposium is a yearly event named for Isabella and Jerome Karle, distinguished graduates of our department, who worked together to advance X-ray crystallography methods. This year’s keynote speaker was Dr. Alan Aspuru-Guzik from the University of Toronto.

The Bailey Lab was represented by rising fifth-year, Marina Sarcinella (above), and rising fourth-year, Krista Meserve (left), who presented their work as posters in the poster sessions. Krista won a travel award for her work on Ebola Virus diagnostics! Great job to both!

In addition to the Karle Symposium, the ALUMINUM (Alumni Networking at UMich) and URANIUM (Undergraduate Research and Networking at UMich) symposia were held last week. Rising senior, Sam Edgcombe (right), presented her work on nanodisc optimization at the poster session. Awesome job, Sam!

Bioanalytical Sensors GRC Recap

A beautiful campus, fascinating science talks, and many hours of networking combined for an exciting week at the bioanalytical sensors Gordon Research Conference. Krista, Nico, Gloria, and Ryan attended the conference held on Salve Regina’s campus in Newport, RI during the last week of June. Professors, post-docs, and graduate students traveled to RI from all over the world to share the latest advancements coming from their labs.

After some tricky travel situations, Gloria, Nico, Krista, and Biteen Lab graduate student Anna Calkins attended the Gordon Research Symposium, a two-day event held prior to the GRC for only post-docs and graduate students. They met new friends and shared their research at the poster sessions.

Ryan kicked off the Monday morning scientific talks by highlighting the lab’s work in his talk titled: “New Directions in (Bio)chemical Sensing Using Droplet Microfluidics”. The graduate students presented their own work at multiple poster sessions throughout the week:


Gloria: DropCUTT – Leveraging the Capabilities of Droplets to Automate Enzymatic Tethering Assays

Nico: Multiparametric analysis via a droplet microfluidic-based, transmission phase grating

Krista: Using Microring Resonators for Detection of Viral Biomarkers
           

Gloria’s poster was voted one of the top four poster presentations and she was invited to give a scientific talk on the last night of the conference. She pulled together an amazing presentation and we are so proud of her for earning this recognition.

Outside of presenting and listening to leaders in the field share their research, the group enjoyed exploring Newport, RI. They wandered downtown to the Wharf and Tennis Hall of Fame, went to a winery, explored the cliff walk, toured Breakers (one of the Newport mansions), and relaxed near the ocean with fellow conference attendees.

One of the week's highlights was making new connections with other graduate students, post-docs, professors, and industry professionals. The group made many great memories and would like to thank the organizers for putting on such a great program of events.

Nick announces internship at Eli Lilly!

We have exciting news to share! This fall Nick will be completing an internship at Eli Lilly in Indianapolis, Indiana! Nick learned of this internship through his awesome networking skills and will now be working as a research and development scientist starting in August. Nick is most looking forward to “learning more about the multidisciplinary approach used in the pharmaceutical industry to develop therapeutic drugs from the lab and to the consumer.” Outside of working in the lab, he notes he is “looking forward to all the sporting events and concerts in downtown Indy!”

We are all so happy for Nick and we can’t wait to hear about all the great things he learns along the way! Congrats Nick!

New publication for the Bailey Lab!

Congratulations to Krista and Ryan for their latest publication in Cell Reports Methods. This work was an exciting intergenerational Bailey Lab project, as Krista worked with 2012 alum, Dr. Abraham Qavi, along with his current research advisor, Dr. Gaya Amarasinghe, and collaborators at Integrated Biotherapeutics, Mapp Biopharmaceutical, Inc., the US Army Medical Research Institute of Infectious Diseases and Washington University. We enjoyed hosting Abe (pictured to the right) for a week while they worked on analyzing the NHP samples for the study!

Rapid detection of an Ebola biomarker with optical microring resonators

Summary:
Ebola virus (EBOV) is a highly infectious pathogen, with a case mortality rate as high as 89%. Rapid therapeutic treatments and supportive measures can drastically improve patient outcome; however, the symptoms of EBOV disease (EVD) lack specificity from other endemic diseases. Given the high mortality and significant symptom overlap, there is a critical need for sensitive, rapid diagnostics for EVD. Facile diagnosis of EVD remains a challenge. Here, we describe a rapid and sensitive diagnostic for EVD through microring resonator sensors in conjunction with a unique biomarker of EBOV infection, soluble glycoprotein (sGP). Microring resonator sensors detected sGP in under 40 min with a limit of detection (LOD) as low as 1.00 ng/mL in serum. Furthermore, we validated our assay with the detection of sGP in serum from EBOV-infected non-human primates. Our results demonstrate the utility of a high-sensitivity diagnostic platform for detection of sGP for diagnosis of EVD.

Find the full article here!

Read WashU’s press release about the article here!

Gloria receives departmental award!

Congratulations are in order for 5th-year graduate student Gloria Diaz, who recently received the Exceptional Service Award from the Michigan Chemistry Department.

Gloria has contributed to the department by participating in recruitment activities and chairing the annual Karle Symposium. She has also been engaged in outreach through social media to connect with scientists of diverse backgrounds!

Great work, Gloria! We are so proud!!

Bailey Lab at the 2022 UM/Agilent Symposium

On Thursday, April 14th, 2022, the first annual UM/Agilent Symposium of Measurement Science was held on the UM campus. The symposium was created to help bridge the gap between academia and industry by providing a platform for scientific discussion and networking. The day was filled with talks by Agilent scientists, students presentations, a poster session, and a panel of Agilent staff who provided great insight into the industry. Krista, Marina, and Nick displayed their work at the poster session and Nick presented his project to the full audience during the student talks. Great work by all!

Thank you to the organizers of the symposium and to Agilent for sponsoring! We can’t wait for next year!

Sam receives undergraduate summer fellowship!

The Bailey Lab’s undergraduate researcher, Sam, was selected for a summer undergraduate research program (SURP) fellowship from the chemistry department! Sam will now be funded to work with us in the lab for 10 weeks of full-time research. Sam has been training on Team Nanodiscs with Marina and has already gained many skills and expertise on the project. Sam is looking forward to spending more hours in the lab to dig into her work and make more progress with her nanodiscs!

We can’t wait to see what Sam accomplishes this summer! Congrats!



Krista wins travel award for third-year seminar presentation!

Each year, third-year graduate students present a brief seminar highlighting the research accomplishments they have made thus far in the program. The analytical cluster’s seminar presentations took place in December 2021 and Krista, our third-year graduate student, presented her latest project: “Detection of Ebola virus soluble glycoprotein using silicon photonic microring resonators”. 

Krista’s presentation earned her one of the two travel awards granted to the highest scoring analytical seminar talks! Congrats to Krista, as well as Hayley Herderschee from the Kennedy Lab, for earning this award!